AustralieFrV1, Main, Exploration, bibRecord, 007C44

Characterization of the thymic IL-7 niche in vivo

Identifieur interne : 007C44 ( Main/Exploration ); précédent : 007C43; suivant : 007C45

Characterization of the thymic IL-7 niche in vivo

Auteurs : Nuno L. Alves [France] ; Odile Richard-Le Goff [France] ; Nicholas D. Huntington [France] ; Ana Patricia Sousa [France] ; Vera S. G. Ribeiro [France] ; Allison Bordack [France] ; Francina Langa Vives ; Lucie Peduto [France] ; Ann Chidgey [Australie] ; Ana Cumano [France] ; Richard Boyd [Australie] ; Gerard Eberl [France] ; James P. Di Santo [France]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2009.

RBID : PMC:2635771

Abstract

The thymus represents the “cradle” for T cell development, with thymic stroma providing multiple soluble and membrane cues to developing thymocytes. Although IL-7 is recognized as an essential factor for thymopoiesis, the “environmental niche” of thymic IL-7 activity remains poorly characterized in vivo. Using bacterial artificial chromosome transgenic mice in which YFP is under control of IL-7 promoter, we identify a subset of thymic epithelial cells (TECs) that co-express YFP and high levels of Il7 transcripts (IL-7^hi cells). IL-7^hi TECs arise during early fetal development, persist throughout life, and co-express homeostatic chemokines (Ccl19, Ccl25, Cxcl12) and cytokines (Il15) that are critical for normal thymopoiesis. In the adult thymus, IL-7^hi cells localize to the cortico-medullary junction and display traits of both cortical and medullary TECs. Interestingly, the frequency of IL-7^hi cells decreases with age, suggesting a mechanism for the age-related thymic involution that is associated with declining IL-7 levels. Our temporal-spatial analysis of IL-7-producing cells in the thymus in vivo suggests that thymic IL-7 levels are dynamically regulated under distinct physiological conditions. This IL-7 reporter mouse provides a valuable tool to further dissect the mechanisms that govern thymic IL-7 expression in vivo.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635771

DOI: 10.1073/pnas.0809559106
PubMed: 19164539
PubMed Central: 2635771

Affiliations:

Le document en format XML

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<author><name sortKey="Vives, Francina Langa" sort="Vives, Francina Langa" uniqKey="Vives F" first="Francina Langa" last="Vives">Francina Langa Vives</name>
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<author><name sortKey="Chidgey, Ann" sort="Chidgey, Ann" uniqKey="Chidgey A" first="Ann" last="Chidgey">Ann Chidgey</name>
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<author><name sortKey="Boyd, Richard" sort="Boyd, Richard" uniqKey="Boyd R" first="Richard" last="Boyd">Richard Boyd</name>
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<front><div type="abstract" xml:lang="en"><p>The thymus represents the “cradle” for T cell development, with thymic stroma providing multiple soluble and membrane cues to developing thymocytes. Although IL-7 is recognized as an essential factor for thymopoiesis, the “environmental niche” of thymic IL-7 activity remains poorly characterized in vivo. Using bacterial artificial chromosome transgenic mice in which YFP is under control of IL-7 promoter, we identify a subset of thymic epithelial cells (TECs) that co-express YFP and high levels of <italic>Il7</italic>
 transcripts (IL-7<sup>hi</sup>
 cells). IL-7<sup>hi</sup>
 TECs arise during early fetal development, persist throughout life, and co-express homeostatic chemokines (<italic>Ccl19</italic>
, <italic>Ccl25</italic>
, <italic>Cxcl12</italic>
) and cytokines (<italic>Il15</italic>
) that are critical for normal thymopoiesis. In the adult thymus, IL-7<sup>hi</sup>
 cells localize to the cortico-medullary junction and display traits of both cortical and medullary TECs. Interestingly, the frequency of IL-7<sup>hi</sup>
 cells decreases with age, suggesting a mechanism for the age-related thymic involution that is associated with declining IL-7 levels. Our temporal-spatial analysis of IL-7-producing cells in the thymus in vivo suggests that thymic IL-7 levels are dynamically regulated under distinct physiological conditions. This IL-7 reporter mouse provides a valuable tool to further dissect the mechanisms that govern thymic IL-7 expression in vivo.</p>
</div>
</front>
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<country name="France"><region name="Île-de-France"><name sortKey="Alves, Nuno L" sort="Alves, Nuno L" uniqKey="Alves N" first="Nuno L." last="Alves">Nuno L. Alves</name>
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<name sortKey="Di Santo, James P" sort="Di Santo, James P" uniqKey="Di Santo J" first="James P." last="Di Santo">James P. Di Santo</name>
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<name sortKey="Goff, Odile Richard Le" sort="Goff, Odile Richard Le" uniqKey="Goff O" first="Odile Richard-Le" last="Goff">Odile Richard-Le Goff</name>
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<country name="Australie"><noRegion><name sortKey="Chidgey, Ann" sort="Chidgey, Ann" uniqKey="Chidgey A" first="Ann" last="Chidgey">Ann Chidgey</name>
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<name sortKey="Boyd, Richard" sort="Boyd, Richard" uniqKey="Boyd R" first="Richard" last="Boyd">Richard Boyd</name>
</country>
</tree>
</affiliations>
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HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007C44 | SxmlIndent | more

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{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:2635771
   |texte=   Characterization of the thymic IL-7 niche in vivo
}}

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       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Characterization of the thymic IL-7 niche in vivo

Characterization of the thymic IL-7 niche in vivo

Source :

Abstract

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Le document en format XML

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Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
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